On the other hand, global hemizygous ROCK2 deficient and cardiomyocyte-specific ROCK2-deficient mice were found to be resistant to pressure overload-induced cardiac hypertrophy and fibrosis formation, supporting that ROCK2 is important in mediating the cardiac hypertrophic response (Okamoto et al. 2013; Sunamura et al. 2018). The gene discussed is ROCK2; the disease is cardiac hypertrophy.