In non-tumor and tumor cells, ROCK1 and ROCK2 have been reported to have functional differences in regulating the actin cytoskeleton, adhesion, migration, proliferation and gene expression, but the underlying mechanisms are not fully understood (reviewed in: Amano et al. 2010; Shi and Wei 2007; Surma et al. 2011; Wei et al. 2016). Here, ROCK2 is linked to neoplasm.