ROCK1 and omphalocele: ROCK1–/– mice in C57BL/6 genetic background were born at expected Mendelian ratios, but exhibited eyelids open at birth (EOB) and an omphalocele phenotype due to disorganization of actin filaments in the epithelial cells of the eyelids and in the umbilical ring (Shimizu et al. 2005).