Consistent with the findings of previous studies, the multivariable analyses in our study showed that age (for AVC and MVC), systolic blood pressure (for AVC), coronary heart disease (for AVC and MVC), diabetes (for AVC and MVC), and Ca × P product (for AVC and MVC) and intact PTH levels (for AVC and MVC) were independently associated with cardiac valve calcification in patients with CKD. The gene discussed is PTH; the disease is chronic kidney disease.