Age (OR: 1.05, 95% CI 1.01–1.09, P = 0.002), diabetes (OR: 2.25, 95% CI 1.21–4.20, P = 0.011), coronary heart disease (OR: 2.91, 95% CI 1.29–6.54, P = 0.010), peripheral vascular disease (OR: 2.86, 95% CI 1.02–7.99, P = 0.045), and the serum levels of Ca × P product (OR: 1.09, 95% CI 1.05–1.13, P < 0.001) and intact PTH (OR: 1.18, 95% CI 1.08–1.28, P < 0.001) were also independently associated with at least one valve calcification. The gene discussed is PTH; the disease is vascular disorder.