Interestingly, similar to Wang et al.’s study16, we found that SIRT1/3 were negatively regulated by MFF, and participated in the regulation of mitochondrial functions and proliferation–apoptosis balance of hypoxia-treated PAMSCs mediated by MFF, which suggesting that SIRT1/3 might be a downstream signaling of MFF in PAH progression. This evidence concerns the gene SIRT1 and pulmonary arterial hypertension.