Although we found that a RNA polymerase III subunit, POLR3A expressions tended to be downregulated in some gliomas suggesting a potential contribution of the downregulation of RNA polymerase III on the lower expression of Alu RNA in gliomas, statistical significances were only attained in A2 and A4 gliomas (Supplementary Fig. 6). Here, POLR3A is linked to central nervous system cancer.