Patients with prediabetes/DM had higher BMI (p < 0.001), WC (p < 0.001), total cholesterol (p = 0.012), LDL-cholesterol (p = 0.004), TG (p = 0.031), fasting glucose (p = 0.002), fasting insulin (p = 0.035), glutamate-pyruvate transaminase (GPT) (p = 0.018), HOMA-IR (p = 0.039), AUC2h glucose (p = 0.001), AUC2 h insulin (p = 0.002), HbA1c (p < 0.001), VAI (p = 0.038) and lower ISI-Matsuda (p = 0.008) and DIo (p < 0.001) than patients with NGT (Table 1). This evidence concerns the gene INS and diabetes mellitus.