These genes include Tenascin C (TNC), Collagen 5A1 (COL5A1), Fibronectin 1 (FN1), and Thrombospondin 1 (THBS1), and genes related to ECM remodelling, including MMP2, Lysyl Oxidase Like 1 (LOXL1) and Procollagen C-Endopeptidase Enhancer 2 (PCOLCE2), which are all known to contribute to breast tumour progression via increased ECM deposition and remodelling as reviewed in31. The gene discussed is PCOLCE2; the disease is breast neoplasm.