TNF and neoplasm: Based on expression differences inferior to the 2.5th percentile of all gene-wise comparisons, 254 genes were considered overexpressed in the primary tumor sample, and these were enriched for gene sets related to immune response programs (i.e., IFNɣ signaling: P = 0.007; and TNFɑ signaling: P = 0.003) and epithelial-to-mesenchymal transition (P < 0.001), which is consistent with the expected enrichment of stroma and immune cells in the primary tumor sample.