Although, single protein Bcl-xL and MCL1 was able to stratify CRC outcome, a combination of Bcl-2, Bcl-xL, MCL1, Bax, and Bak was a better predictor of clinical outcomes, with Bcl-xL and MCL1 being the key dominating proteins [53]. This evidence concerns the gene BCL2 and colorectal carcinoma.