GPX3 and amyotrophic lateral sclerosis: To test if the SNP-ALS association could be mediated through a SNP-gene expression association, we ran SMR using the largest available eQTL sample for whole blood (n = 31,684) to identify GPX3 and TNIP1. The top eQTL SNP (rs1258386, peQTL = 1.1 × 10−171) was in low LD (r2 = 0.13) with the top GWAS SNP (rs10463311).