ATXN3, C9orf72, SCFD1, CAAP1, M0B3B, PLAA, SHMT2, RP11-114F3.5, TRIP11, ZSWIM8 and DYNLL2 all demonstrated at least one genetic component of expression that is associated with ALS (Additional file 1: Table S16-S17). The gene discussed is SHMT2; the disease is amyotrophic lateral sclerosis.