Given the alterations of GPX3 expression in ALS cases and the SMR results for GPX3 and TNIP1, we queried the summary statistics from a methylome-wide association study [46] and conducted a subset of the Australian ALS case-control cohort (Ncases = 782, Ncontrols = 613). The gene discussed is GPX3; the disease is amyotrophic lateral sclerosis.