Interestingly, within cases, we identified a linear association with GPX3 expression and ALS functional rating score (ALSFRS-R (scale from 48 to 0, where 48 is a normal physical function)), p = 6.2 × 10−3, R2 = 0.16, Beffect ± standard error = 125 ± 39 ng/ml/ALSFRS unit, n = 50 ALS cases (Additional file 2: Fig. S9C), to suggest a higher ALSFRS correlated with higher GPX3 (sex included as a covariate). Here, GPX3 is linked to amyotrophic lateral sclerosis.