Even though we cannot yet predict whether this trend will be continued beyond the first 3 weeks after vaccination, a pronounced IgA response combined with a higher virus neutralization capacity following BNT162b2 vaccination may explain its superior effectiveness in preventing symptomatic COVID-19 after both infection with wild type SARS-CoV-2 and its variants [15, 17, 19, 40]. The gene discussed is CD79A; the disease is COVID-19.