CCK-8, colony formation, tumor sphere formation and flow cytometry assays were performed, and the results revealed that cell proliferation (Fig. 8P-R) and cell cycle (Fig. 8S) were inhibited by overexpression of miR-1197 compared with the negative control in UOK109 cells, and ectopic expression of SMAD3 recovered this increase. This evidence concerns the gene SMAD3 and neoplasm.