Xp11.2 translocation renal cell carcinoma (Xp11.2 tRCC), as an independent subset of RCC in the 2016 WHO classification [1], is characterized with poor prognosis of patients caused by high expression of transcript factor E3 (TFE3) fusion gene. The gene discussed is TFE3; the disease is renal cell carcinoma associated with Xp11.2 translocations/TFE3 gene fusions.