The PD1+ EVs median values of the couples responders vs non-responders are 4.86 vs 22.27, 4.71 vs 14.54, 1.18 vs 10.86, 6.87 vs 22.43 and 5.07 vs 21.45 if they come from melanoma cells, CD8+ T cells, B cells, monocytes and DCs, respectively. Here, CD8A is linked to melanoma.