Recent studies have hypothesized that both PD-L1 and PD1 positive exosomes or small EVs and soluble forms of PD1 and PD-L1 may play a key role in response to ICI in MM and be predictors of response as well as we recently demonstrated for uPAR+ EVs [24, 25, 48]. Here, PLAUR is linked to Miyoshi myopathy.