The evaluation of the killing of MM spheroids by PBMCs of various origins in the presence of nivolumab is reported in Fig. 4C. After 96 h, the anti-PD1 increased the cytotoxicity of PBMCs of about 2.4 folds when PBMCs were isolated from blood of MM patient (RES and NRES). Here, PDCD1 is linked to Miyoshi myopathy.