Owing the evidence that the EVs are the main source of circulating PD1 [24], we sought to understand in the same cohort of MM patients, whose data are reported in [25], whether PD1 is expressed on the membrane of circulating EVs and if a putative systemic increase of PD1+ EVs in plasma of patients may cause or correlates with unresponsiveness to anti-PD1. This evidence concerns the gene PDCD1 and Miyoshi myopathy.