However, the PBMCs of MM patients and those of healthy donors differed in number, the main population affected in patients were: i) CD8 T cells, in their totality and the activated ones, and the DCs, both plasmacytoid (pDCs) and conventional (cDCs), which were decreased in patients, ii) the macrophages which were decreased in their totality and more enriched in M2 then M1 population, and iii) the PMN-MDSC and M-MDSC which were, as T reg cells, reduced in responder much more then in non-responder, in agreement with a higher efficacy of ICI in responders (Fig. 4D). This evidence concerns the gene CD8A and Miyoshi myopathy.