Based on the multivariate regression analysis, it was found that parameters such as the type of renal replacement therapy used, the patient’s age, duration of dialysis, and CKD stage affected the activity of XO in PPP, XD in PRP and XO in PRP, respectively, about 33% of XO in platelet-poor plasma, 39% of XD in platelets and 32% of XO in platelets. Here, XDH is linked to chronic kidney disease.