ST6GAL1 and cancer: In the single publication assessing ST6GAL-1 in radiation resistance in cancer cells, Lee et al. (19) transduced the SW480 colon cancer cell line (which has low levels of ST6GAL-1 expression) with ST6GAL-1 and found that it became more resistant to radiation using a clonogenic assay, and that the cell surface protein β1-integrin in these cells had increased Sia after radiation treatment.