Moreover, the HMA/TSP genes were enriched in Pathways of neurodegeneration-multiple diseases, Huntington disease, Metabolic pathways, Prion disease, Alzheimer disease, Parkinson disease, Oxidative phosphorylation, Ubiquitin mediated proteolysis, TGF-beta signaling pathway, Cell cycle, N-Glycan biosynthesis, HIF-1 signaling pathway, MicroRNAs in cancer, Carbon metabolism, and AMPK signaling pathway which are mostly neurological related pathways. The gene discussed is HIF1A; the disease is prion disease.