However, this increase in GPVI expression must also be in the setting of GPVI shedding from activated platelets during the thrombotic event, as reported by Al-Tamimi et al. Therefore, the apparent higher level of GPVI-dimer by day-90 may in fact more accurately reflect the constitutive number of dimers in the patients’ platelets prior to stroke and prior to any GPVI shedding during thrombosis. Here, GP6 is linked to Stroke.