GP6 and stroke disorder: However, this increase in GPVI expression must also be in the setting of GPVI shedding from activated platelets during the thrombotic event, as reported by Al-Tamimi et al. Therefore, the apparent higher level of GPVI-dimer by day-90 may in fact more accurately reflect the constitutive number of dimers in the patients’ platelets prior to stroke and prior to any GPVI shedding during thrombosis.