Previous studies investigating GPVI in thrombotic disease have focussed on either quantifying soluble GPVI (sGPVI), the metalloproteinase-cleaved ectodomain of GPVI shed from the platelet upon activation [21, 22], or on platelet surface expression of total GPVI (the sum of monomeric and dimeric GPVI) [23]. Here, GP6 is linked to thrombotic disease.