With regard to therapeutic options, patients with HR + /HER2 + breast cancer were more likely to receive surgery (91.2% vs 89.4%, P < 0.0001) and radiotherapy (45.0% vs 42.0%, P < 0.0001) compared with HR-/HER2 + patients, while the delivery rate of chemotherapy was relatively lower in the HR + /HER2 + subgroup patients (71.5% vs. 76.6%, P < 0.0001). The gene discussed is ERBB2; the disease is breast cancer.