ZC4H2, an X-linked gene, encodes a C4H2-type zinc-finger nuclear factor, whose mutations have been reported to be associated with various disorders, including arthrogryposis multiplex congeita, X-linked intellectual disability (XLID), Wieacker‒Wolff syndrome, and Miles‒Carpenter syndrome (Hirata et al., 2013; May et al., 2015; Zanzottera et al., 2017; Frints et al., 2019). The gene discussed is ZC4H2; the disease is cask-related x-linked intellectual disability.