Of interest, the study demonstrated that reduced and/or absent expression of E-cadherin in non-small cell lung cancer was responsible for the malignant phenotype, and moreover, aberrant expression of N-cadherin was closely associated with transformation, adhesion, apoptosis, angiogenesis, and invasive metastasis in human malignancies [23,24]. This evidence concerns the gene CDH2 and non-small cell lung carcinoma.