Knockdown of OIP5‐AS1 resulted in increased cell proliferation in renal tissue cells, and its role in the progression to fibrosis has been studied by monitoring renal fibrosis‐related factors (collagen IV (Col‐4), fibronectin (FN), transcriptional regulatory factor‐beta 1 (TGF‐β1)) in relation to the levels of OIP5‐AS1 in renal tissue. This evidence concerns the gene OIP5 and renal fibrosis.