Ischaemic stroke can tempt changes in mitochondrial morphology and function, OPA1, as a regulatory gene in mitochondria, plays a vital role in regulating mitochondrial fission/fusion and other relational functions, a study has indicated that the stabilization of long isoform of OPA1 (L‐OPA1) keeps ischaemic brains via maintaining mitochondrial function and attenuating neuronal apoptosis.68 This evidence concerns the gene OPA1 and ischemic stroke.