Patients with the sole presence of anti–TIF1-γ had a two- to four-fold higher incidence of cancer, whereas anti-CCAR1 antibodies were negatively associated with cancer within three years of diagnosis (OR 0.27, P = 0.05 [Stanford]; OR 0.13, P = 0.008 [Johns Hopkins]). The gene discussed is CCAR1; the disease is cancer.