IL1B and gout: In mice, intraperitoneal administration of monosodium urate (MSU) crystals (the driver of gout) activates the NLRP3 inflammasome (104); however, coadministration of OI with MSU crystals was able to reduce levels of IL-1β, IL-6 (downstream of IL-1β signaling), and neutrophil recruitment in peritoneal lavage fluid (77).