Recent studies have shown the irregulated EIF3 expression in various kinds of developmental diseases and human cancers, such as HNSCC (head and neck squamous cell carcinoma) [38], GBC (gallbladder cancer) [37], OV (ovarian cancer) [39], BRCA [18], HCC (hepatocellular carcinoma) [40] and so on. The gene discussed is EIF3A; the disease is head and neck squamous cell carcinoma.