In this view, it is notable that in our study sCD163 was not associated with the basal concentrations of free fatty acids contrary to nondiabetic and less obese patients (Rosso et al., 2019), which suggests that local intrahepatic events may influence liver macrophage activation to a higher degree than factors produced in the adipose tissue in the setting of morbid obesity, although the observed association with adiponectin indicates at least some degree of cross‐talk with fat depots. This evidence concerns the gene CD163 and morbid obesity.