This is consistent with our previous findings in patients with severe obesity and MAFLD, with low sCD163 levels except in patients with cirrhosis (Kazankov et al., 2015, 2016), who are not common in cohorts of patients undergoing bariatric surgery (Kazankov et al., 2015; Mueller et al., 2015). The gene discussed is CD163; the disease is obesity due to melanocortin 4 receptor deficiency.