Consistently, after acute MI, while both Beclin1+/− and Fundc1 KO caused higher serum LDH level and increased myocardial infarct size compared with wild‐type mice, Fundc1 KO mouse hearts had the highest LDH level and the largest infarct size (Figure 2B,C), confirming that Fundc1 deficiency causes more severe cardiac damage than Beclin1 deficiency after acute MI. Here, BECN1 is linked to myocardial infarction.