Secondly, while starvation mice and Fundc1 transgenic mice caused comparable increased general autophagy activity after acute MI, Fundc1 transgenic mice had higher mitophagy activity and provided more stronger protective effect on mitochondrial and cardiac function than starvation mice after acute MI (Figure 5), further supporting that the amount of mitophagy accounts for very little proportion of the amount of general autophagy and that the mitophagy provides more predominant protective effect on cardiac function after acute MI. Here, FUNDC1 is linked to myocardial infarction.