Several studies have demonstrated the role of Wnt signaling in metastasis; namely, Wnt activation promotes the epithelial–mesenchymal transition program by increasing the nuclear Smai2 expression [39], and liver metastasis of colon cancer cells is accelerated by the nuclear accumulation of β‐catenin and FOXO3 [40]. Here, FOXO3 is linked to malignant colon neoplasm.