Furthermore, AXIN2 and ZNRF3 expression was significantly decreased in C14‐, C24‐, and C45‐derived subclones compared with APC‐mutated conventional‐type CRC organoids (supplementary material, Figure S3B,C), which was a characteristic of CIMP‐high/MSI‐high serrated CRC [12, 22, 37]. This evidence concerns the gene ZNRF3 and colorectal carcinoma.