Furthermore, an IPA using a public database [29] indicated that Wnt/β‐catenin pathways, such as CTNNB1, WNT1, and lithium chloride, are significantly activated in CRC with APC homozygous deletions compared with CRC with RNF43 truncation mutations (supplementary material, Table S3). This evidence concerns the gene RNF43 and colorectal carcinoma.