The above process resulted in identifying 3 genes: NKIRAS2 (NFKB Inhibitor Interacting Ras Like 2), AKTIP (AKT-interacting protein), and HLA-DQA1 (Major histocompatibility complex, class II, DQ alpha 1), able to distinguish between normal urothelium and the primary urothelial carcinoma with a predictive ability of 94% using a preexisting public patient dataset. This evidence concerns the gene HLA-DQA1 and urothelial carcinoma.