Astonishingly, we found that all nine selected genes of the tumorigenic network were significantly expressed and that the seven highly resistant PDX models with progressive disease (PD) identified in Cluster 1 exhibit the highest transcript expression for VEGFA, MET, EGFR, KDR, and PTGS2 within the complete NSCLC cohort. The gene discussed is VEGFA; the disease is non-small cell lung carcinoma.