These pathways are blocked at the receptor level while inhibiting multiple generic intracellularly connected downstream pathways involved in tumor development and treatment resistance such as the mitogen-activated protein kinase (MAPK), Janus kinase and the signal transducer and activator of transcription protein (JAK/STAT), phosphoinositide 3-kinase (PI3K), protein kinase B (AKT), and protein kinase C (PKC) pathways (Fig. 1)11. This evidence concerns the gene AKT1 and neoplasm.