ADAM12 and peripheral arterial disease: Metalloproteinase domain-containing protein 12 (ADAM12) has been identified as a key gene related to modification of PAD severity in mice23, and forced miR-29a expression inhibited the ADAM12 expression in ischemic endothelial cells; in addition, knock-down of miR-29a improved the impaired post-ischemic angiogenesis in a diabetic mouse model24.