We showed that AMIGO2-containing EVs derived from AMIGO2-expressing gastric cancer cells (MKN-28 A1 & A2) enhanced the adhesion of HHSECs to the same gastric cancer cells (MKN-28) as well as to different gastric cancer cells (MKN-74) and colorectal cancer cells (SW480) (Fig. 3c–e). This evidence concerns the gene AMIGO2 and colorectal cancer.