In addition, the group containing only RNF43 or ZNRF3 mutations was also enriched on gene sets of “NASH”, “simple steatosis”, “Fatty acid metabolism”, “cholesterol biosynthesis” and “adipogenesis” (Supplementary Fig. 8c and Supplementary Data 6_S25–S30). Here, ZNRF3 is linked to metabolic dysfunction-associated steatohepatitis.