Our findings might seem at odds with reported results whereby WNT3A injection prevents lipid accumulation in mice with active non-canonical WNT through an LRP6 receptor mutation (LRP6R611C)52,53 and with the phenotype of the core canonical WNT component APC in the liver, which results in HCC without the need of any additional hit or tissue damage37. This evidence concerns the gene APC and hepatocellular carcinoma.