RNF43 and neoplasm: Using multivariate survival analysis accounting for WNT mutation, RNF43 or ZNRF3 mutation, double RNF43 /ZNRF3 mutation, donor sex and clinical tumour stage, we observed a significant difference in the effect of RNF43 or ZNRF3 mutation on survival depending on whether or not a mutation in WNT was also present (interaction term p value 0.049, Supplementary Data 6_S13).