Accordingly, lower phosphorylation levels of p-HER2 (Tyr1248), p-EGFR (Tyr845), p-Akt (Ser473), p-mTORC1 (Ser2448), and p-GSK3β (Ser9) were observed in tumor tissue after combination treatment with 1,25(OH)2D3 and si-LL-37, compared to 1,25(OH)2D3 treatment alone (Fig. 7G). The gene discussed is GSK3B; the disease is neoplasm.