In line with the above findings from cell lines, correlation analysis in tumor tissues from 30 GC patients also indicated significant positive relationships between EDDM3A and the glycolytic genes of GLUT1, HK2, PKM2, and LDHA, while a significant negative correlation between EDDM3A and PGC-1α (Fig. 7G). Here, PPARGC1A is linked to gastric cancer.