BCL2 and acute myeloid leukemia: Venetoclax (an oral highly selective Bcl-2 inhibitor) in combination with HMA, as opposed to venetoclax single-agent therapy, has shown promise in refractory/relapsed AML (defined as refractory or relapsed after one induction regimen of either intense or less intense (inclusive of HMA alone), or relapse post-AHSCT) [24–26].