LEP and Paralysis: In other studies using single marker protein measures in NESDA, higher CRP was associated with increased appetite (Lamers, Milaneschi, de Jonge, Giltay, & Penninx, 2018) and higher leptin with mood dependent on the time of day, decreased appetite, increased appetite, weight gain, reduced energy level, pains, other bodily symptoms and leaden paralysis (Milaneschi, Lamers, Bot, Drent, & Penninx, 2017).