Exosomes from hypoxic granulocytic MDSCs can promote the stemness of CRC cells through S100A9 [15], and exosomes from hypoxic glioma cells can induce stronger MDSC expansion and activation through the miRNA-10a/Rora, miRNA-21/PTEN, miRNA-29a/Hbp1 and miRNA-92a/Prkar1a pathways [230, 231]. Here, S100A9 is linked to colorectal carcinoma.