IL6 and neoplasm: Exosomes from normoxic CAFs can inhibit mitochondrial oxidative phosphorylation, thereby increasing glycolysis and glutamine-dependent reductive carboxylation in cancer cells, which is similar to hypoxia-induced metabolic alterations [213], and exosomes from tumor cells can activate hepatic stellate cells to secrete IL-6, which then regulates the lactate metabolism of hypoxic tumor cells [214].