AKT1 and neoplasm: Other HIF-independent factors include the AKT signaling pathway involving miR-21 [124]; conserved sites for the transcription factor Oct-4 in miR-210 [125], the transcription factor TWIST1 in miR-10b [126], and the transcription factor C/EBP-a/RUNX-1 in miR-424 [127]; sites for TET2 and TET3 (DNA-demethylating enzymes) in WT1 lncRNA [128], acetylation levels in the lncRNA-LET promoter region [129] and epidermal growth factor receptor (EGFR) suppression of some specific tumor-suppressor-like miRNAs in response to hypoxic stress through phosphorylation of argonaute 2 (AGO2) at Tyr 393 [130].