It has also been demonstrated that RAB27b regulates the motility of MVEs toward the plasma membrane [39], both RAB27a and RAB27b facilitate the docking of MVEs to the membrane [39], RAB7 plays a role in transporting MVEs to lysosomes for degradation [40], and (coincidentally) hypoxia can increase exosome release by upregulating RAB27a and downregulating RAB7 in ovarian cancer cells [41]. The gene discussed is RAB27A; the disease is ovarian cancer.