To minimize lineage-specific effects, we analyzed whole-genome dropout screen dataset in KRAS-mutant lung (H460, H2122), colon (DLD-1), acute promyelocytic leukemia (NB4) and acute myeloid leukemia (SKM-1) cancer cells, which identified 21 common genes whose loss of function is synthetic lethal with mutant KRAS alleles in distinct cancer lineages (Fig. 1A; Table S4). Here, KRAS is linked to cancer.