GSEA of transcriptomic dataset [36] revealed that NOP56 knockdown significantly enriched the genes involved in the unfolded protein response/UPR (a set of 113 genes upregulated during UPR) in KRAS-mutant cancer cells (Fig. 2A), suggesting that tumor cells might engage the UPR to protect from NOP56 KD-induced surge of cytotoxic ROS. Here, KRAS is linked to cancer.