AKT1 and neoplasm: Immunohistochemical (IHC) analysis revealed that the anti-tumor efficacy of combined treatment with shNOP56 and rapamycin was paralleled by marked decrease of mTOR activity (p-AKT, p-mTPOR, p-S6) and increase in apoptosis (Caspase-3) in the residual tumors (Fig. S5A).