ALK and non-small cell lung carcinoma: Up to now, surgical resection, stereotactic radiosurgery (SRS), and whole brain radiotherapy (WBRT) have been the mainstream strategies for symptomatic or unstable CNS metastases; nonetheless, these treatment options may cause radio-necrosis (RN) and impairment in cognitive function, with some researchers even reporting that ALK+NSCLC patients were especially prone to develop RN (HR 6.36, p < 0.001) [12–14].