CLDN7 and colitis: We used previously constructed inducible intestinal conditional Cldn7 gene knockout (Cldn7fl/fl; villin-CreERT2, abbreviated as CreERT2) and control (Cldn7fl/fl; villin-CreW, abbreviated as CreW) murine models, and intraperitoneally injected tamoxifen (1 mg in 100ul sterile sunflower oil, every 4 days) for 5 consecutive inductions, followed by drinking water for 7 days and 2.5% DSS treatment for 7 days to establish the experimental colitis model.