Fibrosis is a critical pathology of NAFLD, and our findings indicated that the miR-665-3p antagomir dramatically ameliorated HFD-induced hepatic fibrosis, as evidenced by the decreased hepatic hydroxyproline content and mRNA levels of fibrotic markers, including Col1α1, Col3α1, CTGF and TGF-β1 (Figure 1(g) and Figure S1I). Here, CCN2 is linked to Hepatic fibrosis.