ITIH4 and HIV-1 infection: Interestingly, mD1.22-DM1 was able to bind to gp120, inhibit HIV-1 infection, inactivate cell-free HIV-1 virions, but could not significantly kill LRA-activated latent cells (Fig. 1), possibly because the ACH-2 cells is not fully reactivated at low concentration of LRA (16).