To examine whether JIB-04 targets SARS-CoV-2 spike (S) protein-mediated entry or other postentry pathways (e.g., translation, replication, or assembly) shared between SARS-CoV-2 and other viruses, we tested JIB-04 against vesicular stomatitis virus (VSV) that expresses enhanced green fluorescent protein (eGFP) as a marker of infection (34) and a replication-competent chimeric VSV that harbors SARS-CoV-2 S protein in lieu of the native glycoprotein (G) and also expresses eGFP (VSV-SARS-CoV-2) (35). This evidence concerns the gene ART4 and infection.