Of the 16 variants in nine genes found in three cancer databases, we identified seven nonsynonymous SNPs, except unknown variants with MAF ≤ 0.05, including five SNPs (p.Thr343Ile, p.Met357Ile, p.Glu364Ala, p.Glu364Asp, and p.Ser366Thr) in MUC3A and two SNPs (p.Ser7Asn and p.Gly8Val) in PRSS3 (Table 4). The gene discussed is PRSS3; the disease is cancer.