MUC3A is a member of the membrane mucin gene family that encodes secreted and membrane bounding epithelial glycoproteins and also referred to as a potent modifier of epidermal growth factor receptor and is known to lead to poor prognosis by upregulated and downregulated expression of programmed cell death-ligand 1 in non-small cell lung cancer [37]. The gene discussed is CD274; the disease is non-small cell lung carcinoma.