SHC2 and neoplasm: To analyze the variants associated with OGCT development and recurrence, we focused on 44 tumor-specific nonsynonymous variants in 22 genes (PABPC3, ZNF595, MUC3A, OR2T4, SEC22B, PRSS3, NBPF14, NBPF19, NBPF26, NBPF9, FEZ2, ANKRD36C, ANKRD36B, GYPA, PRIM2, VWDE, CFTR, NUTM2A, MUC6, OR8U1;OR8U8, GOLGA6L3, TPSD1, NPIPB15, SHC2, and KRTAP10-6) and four tumor-specific frameshift indels in ZNF595 (Table 3).