To exclude the potential heterogeneity of ADSCs between mice and rats, we next used a Sprague‐Dawley rat MI/R model to assess the cardiac homing and cardioprotective effects of rat ADSCs, which were isolated from transgenic rats expressing tdTomato (ADSC‐Tomato) and then treated with irisin (ADSC‐Tomato‐irisin) or vehicle (ADSC‐Tomato‐vehicle) for 2 days. The gene discussed is FNDC5; the disease is myocardial infarction.