C57BL/6J mice were subjected to myocardial ischemia‐reperfusion (MI/R) and then administered either vehicle‐treated ADSCs (ADSC‐vehicle, intravenous injection of 5 × 105 ADSC‐vehicle at 1, 8, 15, 22, and 29 days after the MI/R operation) or irisin‐treated ADSCs (ADSC‐irisin). The gene discussed is FNDC5; the disease is myocardial ischemia.