This evidence, together with the demonstration of expression of Gpr54 in the oocyte in rodent, canine and porcine species (Saadeldin et al., 2012; Dorfman et al., 2014; Cielesh et al., 2017), suggested that direct kisspeptins actions in the oocyte may play a relevant role in the control of ovulation, whose failure would lead to early ovulatory failure, reminiscent of premature ovarian insufficiency (POI). This evidence concerns the gene KISS1R and Premature ovarian insufficiency.