PDK1 and Infertility: Thus, elimination of intracellular signaling factors, such as PTEN (Phosphatase and Tensin Homolog delted on Chromosome 10), PDK1 (Phosphoinositide-dependent Kinase 1) and mTOR (mammalian Target of Rapamycin), which are essential to maintain the quiescence state of primordial follicles, resulted in premature activation of primordial follicle growth, leading to complete exhaustion of the ovarian follicular reserve and infertility before 3 months of age (Reddy et al., 2008, 2009; Adhikari et al., 2010).