This evidence, together with the demonstration of expression of Gpr54 in the oocyte in rodent, canine and porcine species (Saadeldin et al., 2012; Dorfman et al., 2014; Cielesh et al., 2017), suggested that direct kisspeptins actions in the oocyte may play a relevant role in the control of ovulation, whose failure would lead to early ovulatory failure, reminiscent of premature ovarian insufficiency (POI). Here, KISS1 is linked to Premature ovarian insufficiency.