Multivariate logistic regression analysis disclosed that age (≥60 years V < 60 years) (P < 0.001), dyspnea (yes V no) (P < 0.001), lymphocyte count (low V normal) (P < 0.001), CRP (high V normal) (P < 0.001) and IL-6 (high V normal) (P < 0.001) were independent factors in prewarning the severe disease occurrence of COVID-19 (Table 3), which may help clinicians early and timely treatment. The gene discussed is IL6; the disease is COVID-19.