In the TME, certain cells, such as TAMs and CAFs secrete proangiogenic factors by induction of hypoxia [62], such as the vascular endothelial growth factor (VEGF), which can create a pro-tumor microenvironment by increasing the inhibitory function of immune cells, such as Tregs, TAMs, and MDSCs, and directly inhibit the function of cytotoxic T lymphocytes (CTLs) [63]. Here, VEGFA is linked to neoplasm.