Inhibition of EGFR, DDR1, ABL1 and related kinases produces a positive IR-DR score. Extensive data link EGFR and inhibitors of EGFR to insulin resistance and neurodegeneration. Pro-inflammatory signalling via iRHOM2 and MAP3K7; circulating biomarker of insulin resistance and hepatic metabolic disease. The gene discussed is EGFR; the disease is Insulin resistance.