We analyzed the genes that correlated with KRT16 (correlation score > 0.5) in TCGA database to investigate the mechanism of KRT16 in NPC and identified that the Ras signaling pathway was significantly enriched (Figure 4a), in which Raf1, MEK and ERK were enriched (Figure 4b). The gene discussed is KRT16; the disease is nasopharyngeal carcinoma.